Stomatitis and dermatophytosis coincident to streptomycin therapy.

Four cases of streptomycin stomatiti are presented together with three cases of eczematous dermatitis of the hands and feet coincident with streptomycin therapy, and attention is called to association of stomatitis with a vulvar mycotic lesion in one instzmce and Concomitant stomatitis with severe trichophytoid lesions of hands and feet in another. While the over-all series of treatment with streptomycin a t this institution embraces a period of 28 months and 130 cases, i t is notable that the pharyngeal ulcers to be described occurred relatively rarely in this series. Recrudescence of pre-ezisting trichophytosis was observed while the patient was undergoing streptomycin therapy. In each of the severe cases of eczematoid dermatitis to be described, a pre-existing trichophytosis of the feet was noted. In the light of the history of previous fungus infection, it is perhaps not illogical to infer that streptomycin therapy tends, in some cases a t least, to give impetus to the trichophytosis already present.